Ck-beta-6 |
Ck-beta-8 |
DVLAGLSSSCCKWGCSKSEISSLC |
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[Met-chemokine-beta-7; Met-Ck-beta-7] abbr. also Ckb7. This factor prevents signaling through the CCR3 chemokine receptor and is highly specific in blocking chemotaxis of eosinophils induced by CCR3 ligands (eotaxin, eotaxin-2, MCP-3, MCP-4, RANTES). For a possible receptor see: GPR30 [G-protein-coupled receptor-30].
Met-Ck-beta-7 is a modified form of MIP-4 (also known as PARC, AMAC-1, or DC-CK1) (Nibbs et al, 2000). The enhanced activity of
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