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Climbing fibers

This term refers to the axons of neurons in the inferior olive of the cerebellum that project to the cerebellar cortex (Eccles et al, 1966). These axons bifurcate into about seven branches in their paths, and each branch terminates as a climbing fiber in the cerebellar cortex (Sugihara et al, 1999).

Climbing fibers synapse on the proximal dendrites of a Purkinje cell but not on its distal dendrites, which forms synapses with parallel fibers. Climbing fibers also connect to other targets like molecular layer cells (stellate cells, basket cells, and NG2-positive glial cells) (Sugihara et al, 1999; Lin et al, 2005).

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