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Clonorin

This pore-forming peptide has been deduced from a cDNA clone of Clonorchis sinensis (clonorin). Clonorin contains six invariably conserved cysteine residues highly homologous with pore-forming peptides known as amoebapores and is considered a member of the family of saposin-like proteins (see: SALIPS). Recombinant clonorin is hemolytic for rabbit erythrocytes. Clonorin is expressed developmentally in juvenile and adult flukes and localizes in the intestinal epithelium of adult flukes.

For other relevant entries see also the Pathogenicity/Virulence Factors Dictionary section of this encyclopedia.

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