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Collagen type 15

[collagen-15; type 15 collagen] approved gene symbol: COL15A1 [collagen-15-alpha-1]. Fragments derived of this protein have been implicated in angiogenesis. See: Restin.

Lisignoli et al (2009) have identified the COL15A1 gene as the most up-regulated gene in osteoblasts compared with bone marrow stromal cells. Expression increases significantly during the osteogenic differentiation of bone marrow stromal cells in vitro. Free extracellular calcium significantly down-modulates its expression. Collagen type 15 is expressed in bone tissue biopsies mainly by working osteoblasts forming new bone tissue or lining bone trabeculae.

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