contra-IL1 |
contraction-band necrosis |
sNPF1 |
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The biochemically uncharacterized factor described by Maki et al (1986) is found in the conditioned medium of AS-9 cells, a T-cell hybridoma line derived from fusion of BW5147 thymoma and splenic T-cells of C3H mice treated with antisera against lymphocytes.
The factor inhibits the generation of allogeneic cytotoxic T-lymphocytes and the proliferation of T-cells in response to alloantigens and mitogens. The factor does not inhibit responses of B-cells to bacterial lipopolysaccharides or the growth of tumor cells and fibroblasts. The factor suppresses the proliferation of CTLL-2
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