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Copeptin is a glycopeptide of 39 amino acids (ASDRSNATQLDGPAGALLLRLVQLAGAPEPFEPAQPDAY) encoded as the C-terminal part of the large precursor for vasopressin (pre-proAVP) (hence sometimes abbr. ct-proAVP [carboxyterminal-pro-AVP] (Holwerda, 1972; Smyth and Massey, 1979; De Bree and Burbach, 1998). Copeptin is encoded by exon 3 of the vasopressin precursor (Land et al, 1982; Ivell and Burbach, 1991).
Its physiological function is unknown. Copeptin may play an important role in the correct structural formation of the Arginine-vasopressin precursor, which is required for its proteolytic maturation efficiency (Barat et al, 2004).
Copeptin is highly stable ex vivo even for several days at room temperature. The determinations of copeptin plasma
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