copine-7 |
COP-I |
parvalbumin neurons |
||
abbr. COP-I. Copolymer-I is a random polymer of four amino acids (glutamic acid, lysine, alanine, and tyrosine) enriched in myelin basic protein, one of several putative autoantigens in multiple sclerosis. These peptides are capable of suppressing experimental autoimmune encephalomyelitis, an animal model for multiple sclerosis, and provide a treatment option for multiple sclerosis (Aharoni et al, 1997; Miller et al, 1998; Scott, 2013). The compound is known also under their commercial names, Glatiramer acetate or Copaxone.
Copolymer-I is thought to act on T-cells to regulate the production of Th1 cytokines and Th2 cytokines (Aharoni et al, 1997; Miller et al, 1998; Duda et al, 2000). It may also inhibit
...
...
...
...
... Subscribe to continue reading!
... ...
Content view restricted ! |