Cytomegalovirus UL22A protein |
Cytomegalovirus UL33 protein |
CKLF-like MARVEL transmembrane domain-containing protein 2 |
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This protein is encoded by the UL26 gene of human cytomegalovirus. It exists as a long and a short isoform (27 kDa, 21 kDa, respectively) (Stamminger et al, 2002). UL26 is a tegument protein critical for high-titer HCMV replication. It is present throughout the viral life cycle and transcribed as an early gene (Abate et al, 2004). At the onset of infection, the majority of UL26 protein localizes to the nucleus, then becomes increasingly cytoplasmic, and eventually localizes to viral assembly sites (Munger et al, 2006). Viral UL26 deletion mutants replicate with slower kinetics, produce plaques of reduced size, and grow to lower final titers (Munger et al, 2006; Lorz et al, 2006)
Mathers et al (2014) have implicated UL26 in innate immunity, showing that
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