Cytomegalovirus UL26 protein |
Cytomegalovirus UL36 protein |
IFN-beta(150-187) |
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This protein is encoded in the genome of human cytomegalovirus. The protein is a virus-encoded G-protein-coupled receptor that heteromerizes with the chemokine receptors CCR5 and CXCR4 and negatively modulates their functional properties, including their HIV co-receptor activity. UL33 dramatically reduces the responsiveness of THP-1 monocytes to CXCL12 (Tadagaki et al, 2012).
UL33 has been shown also to heteromerize with the HCMV-encoded US28 and to inhibit the constitutive activation of the transcription factor NF-kappa-B by US28 (Tschische et al, 2011).
Human
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