DEDD |
DEDDD |
HYBID |
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(approved gene symbhol) [death effector domain-containing DNA-binding protein-2] this protein is related to DEDD and contains a death effector domain (Roth et al, 2002). An alternative name is FLAME-3. Highest levels of DEDD2 mRNA are found in human adult liver, kidney, and peripheral blood leukocytes. DEDD2 interacts with FLIP, but not with FADD or caspase-8. Overexpression of DEDD2 induces moderate apoptosis and results in substantial sensitization to apoptosis induced by FAS antigen, TRAIL, or FADD. Expression of DEDD2 does not affect apoptosis mediated by
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