Cytokines & Cells Online Pathfinder Encyclopaedia
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[Death effector domain-containing testicular molecule] The protein has been identified independently as DEDD.
DEFT transcripts are expressed in a variety of human and rat tissues, with particularly abundant expression in testis germ cells. The protein contains a death effector domain with a high degree of homology to a similar sequence motif in FADD and the inactive polypeptide precursors (zymogen) of caspase-8 and caspase-10. Overexpression of DEFT does not induce cell death by apoptosis in Chinese hamster ovary cells. Its role in apoptotic processes remains to be elucidated.
For other entries pertaining to cell death mechanisms see also the Apoptosis Dictionary section of this encyclopedia.
LAST MODIFIED: January 2002
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