DHX29 |
DHX36 |
Growth stimulatory activity for TS1 cells |
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[DEAH box polypeptide 33]; abbr. also: DDX33 [DEAH box protein 33] or DEAD/H BOX 33. This protein has been identified by Zhang et al (2011) as a member of a larger family of RNA helicases containing a DEAD box. DHX33 is a nucleolar protein and is subject to cell cycle regulation. DHX33 knock-down decreases the association of Pol I with rDNA and causes a dramatic decrease in levels of rRNA synthesis. DHX33 overexpression enhances 47S rRNA synthesis by promoting the association of RNA polymerase I with rDNA loci. DHX33 deficiency in primary human fibroblasts triggers a nucleolar p53 stress response
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