Drosophila Immune-induced Molecule 33 |
Drosophila insulin-like peptides |
VFDSLGGYEVHGF |
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abbr. DIMs. These molecules, identified originally by Uttenweiler-Joseph et al (1998), Levy et al (2004), and Verleyen et al (2006), comprise a large number of immune-induced peptides. After bacterial challenge, they appear in hemolymph with the same kinetics as the antimicrobial peptides and are thought to play a role in innate immunity. The molecular function of most of these proteins are not known.
The appearance of these peptides does not seem to involve the imd [Immune Deficiency] pathway, which is known to play a central role in the control of immune responses towards bacterial infections in Drosophila melanogaster. Levy et al (2004) have used Drosophila melanogaster mutants to show that the expression of most of the 24
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