esculentins |
ESDTVTCRKMKGKCSFLLCPFFKRSSGTCYNGLAKCCRPFW |
Hepatopoietin B |
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[endothelial and smooth muscle cell-derived neuropilin-like molecule] The approved gene symbol is DCBLD2 [Discoidin CUB and LCCL domain-containing protein 2].
The cDNA for this protein has been isolated from a primary culture of human coronary arterial cells (Kobuke et al, 2001). ESDN is a type 1 transmembrane protein containing a CUB domain, a coagulation factor V/VIII homology domain, and an LCCL domain. The protein is potentially secreted and contains the longest signal sequence known in eukaryotes.
ESDN mRNA is expressed in various tissues but prominent in cultured vascular smooth muscle cells and lower in endothelial cells. In
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