EAST |
East Lansing Tyrosine Kinase |
ESP13.2 |
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symbol: Ea. This Drosophila melanogaster extracytoplasmic serine protease is encoded by gene CG4920. Chasan and Anderson (1989) have cloned the cDNA encoding easter. Easter is essential for the establishment of a normal dorsal-ventral pattern in embryos. Loss-of-function mutations result in a dorsalization of the embryonic pattern, whereas dominant gain-of-function mutations ventralize the embryonic pattern. Easter is produced as an inactive zymogen form. Proteolytic processing of the zymogen form of Easter requires the sequential action of Gastrulation-defective, and Snake
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