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Ep1.B is a C-terminally-derived peptide (TQQIRLQAEIFQAR) of apolipoprotein E and corresponds to ApoE(239-252) [Apolipoprotein E(239-252)]. It has been shown to possess anti-atherogenic activity.
Ep1.B reduces neointimal hyperplasia after vascular surgery in rats and mice and prevents plaque growth when given during early plaque progression in wild-type and apolipoprotein E knock-out mice (Bocksch et al, 2007). The peptide also induces a dendritic cell phenotype in human and mouse monocytic cell lines, mouse
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