Epsilon cells
[epsilon cell]
Prado et al (2004) have shown that absence of the homeodomain protein Nkx2.2, which is essential for the differentiation of all beta-cells and a subset of A-cells, contain relatively normal sized islets, but a large number of cells within the mutant islets that fail to produce any of the four major islet hormones. These cells are seen also in mutant mice lacking expression of Pax4.
In mutant animals islet endocrine cells are replaced by cells that produce the hormone ghrelin. These cells, termed epsilon cells, are found in low numbers also in normal mouse
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