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FAS-beta

FAS-beta is generated by alternative splicing of the FAS antigen mRNA (see also: APO-1).

P815 mastocytoma cells transfected with FAS-beta become resistant to cell death by apoptosis induced by FAS ligand. Resistance is mediated by a secreted product of the transfected cells.

In vivo, FAS-beta mRNA expression is correlated inversely with apoptosis among subsets of intrahepatic T-lymphocytes known to be a cell population in which activation induced T-cell apoptosis occurs. FAS-beta may thus be a cytokine that acts physiologically to limit apoptosis induced by FAS ligand.

For other entries pertaining to cell death mechanisms see also the Apoptosis Dictionary section of this encyclopedia.

See REFERENCES for entry FAS-beta

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