FAS-beta

FAS-beta is generated by alternative splicing of the FAS antigen mRNA (see also: APO-1).

P815 mastocytoma cells transfected with FAS-beta become resistant to cell death by apoptosis induced by FAS ligand. Resistance is mediated by a secreted product of the transfected cells (Hughes and Crispe, 1995).

In vivo, FAS-beta mRNA expression is correlated inversely with apoptosis among subsets of intrahepatic T-lymphocytes known to be a cell population in which activation induced T-cell apoptosis occurs. FAS-beta may thus be a cytokine that acts physiologically to limit apoptosis induced by ... ... ... ...
 
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Entry last modified: June 1996