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FDMF

[fibroblast-derived motility factor] This biochemically uncharacterized factor has been found in conditioned medium from gingival fibroblasts grown in serum-free medium. It stimulates Chemotaxis and Chemokinesis of adenoid cystic carcinoma cells. The physicochemical properties of FDMF appear to be different from any of the known Motogenic cytokines.

Exposure of adenoid cystic carcinoma cells to FDMF is associated with a reduction in the amounts of actin stress fibers in the cytoplasm. Treatment of the cells with FDMF leads to tyrosine phosphorylation of several cellular proteins. The effects of FDMF are blocked by treatment with Genistein ... ... ... ... ... Subscribe to continue reading! ... ...

 

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