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GEBP11

This targeting peptide, CTKNSYLMC, has been identified by phage display library screening for peptides binding specifically to human umbilical vein endothelial cells co-cultured with gastric cancer cells. The peptide shows strong preference for co-cultured endothelial cells as opposed to control endothelial cells and also recognizes vascular endothelial cells in gastric cancer tissue sections.

Zhang J et al (2013) have reported that an iodine 131-labelled pegylated trimeric GEBP11 significantly suppresses tumor growth in vivo, significantly decreases the vasculature, and prolongs survival times.

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