GM-CSF |
GM-CSF augmenter |
CASP11 |
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abbr. GIF (a term with multiple meanings). abbr. vGM-CSF/IL2BP. This factor is encoded in the genome of the parapoxvirus orf virus (gene ORFV117). The gene is expressed as an intermediate-late viral gene in orf virus-infected cells.
The viral protein forms homodimers and tetramers in solution and functions as a soluble protein inhibitor of ovine GM-CSF and IL2 and binds ovine GM-CSF with a K(d) of 369 pM and ovine IL2 with a K(d) of 1.04 nM. The viral protein does not bind human GM-CSF or IL2 (Deane et al, 2000).
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