GRAL-B |
GRAMD4 |
PR domain containing 1 |
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[Granulocyte-activating mediators] This biochemically uncharacterized factor (17 and 44 kDa) is released by human epidermal cells and the epidermoid carcinoma cell line A431 (epidermal cell-derived granulocyte-activating mediator, abbr. EC-GRAM. Factor production is enhanced by bacterial lipopolysaccharides, but not by silica particles and phytohemagglutinin. The activity stimulates human granulocytes to release significant levels of toxic oxygen radicals.
Monocytes release M-GRAM (monocyte-derived GRAM) upon stimulation with bacterial lipopolysaccharides
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