Gene therapy |
Genetically engineered cytokines |
RH2 |
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Genetic ablation, called also genetic amputation or cell ablation or tissue ablation, is a technique that can be used to suppress selectively the growth of a certain predetermined cell population in a living organism. The term genetic ablation is used, however, also for genetic modifications disrupting the activity of an individual gene by gene targeting (see: knock-out), for example in ES cells or mice derived thereof.
This approach essentially involves construction and expression of a gene under the control of a gene promoter that is known to be active only in a certain cell type (see also: gene expression). This promoter can be used to drive expression of a cytotoxic protein (see also:
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