HRKKHHGKRNSNRAHQGKHETYGHKTPY |
HRNLFQVDDPFFATRamide |
VFRLKKWIQKVIDQFGE |
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this is a synthetic peptide, RNPRGEEGGPW, derived from two conserved sequence segments of the first kringle domain of HGF [hepatocyte growth factor] (Xu et al, 2010). The peptide has been shown to inhibit corneal neovascularization by inducing endothelial apoptosis and arresting the cell cycle (Sun et al, 2013).
Wang L et al (2014) have reported that H-RN shows anti-inflammatory effects in models of experimental ocular inflammation, including endotoxin-induced uveitis and experimental autoimmune uveitis, suppressing clinical manifestation of the disease and inhibiting ocular inflammatory
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