HIAP2 |
HIB-1B |
SSTR2 |
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[hypoxia-induced angiogenesis regulator] This protein, encoded by the human NCBP2AS2 [NCBP2 antisense 2; NCBP2 antisense RNA 2] gene, has been identified by Kugeratski et al (2019) as a protein expressed abundantly in human mammary cancer-associated fibroblasts under conditions of hypoxia. Silencing of HIAR abrogates the pro-angiogenic and pro-migratory function of hypoxic cancer-associated fibroblasts by decreasing secretion of the pro-angiogenic factor VEGF-A. HIAR promotes tumor angiogenesis by causing increased secretion of VEGF-A, which leads to endothelial sprouting. The protein acts intracellularly but also appears to be secreted.
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