HPN |
hpo |
prostatein |
||
[Helicobacter pylori neutrophil activating protein] HP-NAP is encoded by the napA gene of Helicobacter pylori (Evans et al, 1995). HP-NAP is an unusual, small, ferritin that folds into a four-helix bundle that oligomerizes into dodecamers with a central hole capable of binding up to 500 iron atoms per oligomer (Tonello et al, 1999). However, HP-NAP synthesis is not regulated by iron depletion or overload or by the presence of copper, nickel or zinc, suggesting that the primary role of the protein in vivo is not as a metal-binding protein (Dundon et al, 2001).
An important role of this factor in immunity is suggested by the observation that vaccination of mice with HP-NAP protects them against Helicobacter pylori challenge and that the majority of infected patients produce antibodies specific for HP-NAP (Satin et al, 2000).
HP-NAP is
...
...
...
...
... Subscribe to continue reading!
... ...
Content view restricted ! |
| SUPPORT COPE | Intro | Subdictionaries | New Entries | Contribute data | COPE Credentials |
| # | A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z |
|
Created, developed, and maintained by Dr H Ibelgaufts
|
U L T R A P O S S E N E M O O B L I G A T U R