HPP-Mix |
HPP-Q BFU-E |
IML-3 |
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[High proliferative potential-quiescent cells] Human HPP-Q cells have been defined as primitive quiescent or slow cycling hematopoietic stem cells or progenitor cells (Fortunel et al, 1998). These human cells are CD34(+) and CD38(-) and possess the potential to generate in vitro very large colonies in a colony formation assay, utilizing a medium containing IL3, IL6, IL11, G-CSF, GM-CSF, SCF, erythropoietin (Fortunel et al, 2000).
Quiescence is caused by TGF-beta-1, which, even at low
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