Hedgehog |
Hedgehog-interacting protein 1 |
7SL remnant |
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abbr. HIP. Approved gene symbol: HHIP; abbr. also HHIP1 [Hedgehog-interacting protein 1]. The murine cDNA for this type-1 transmembrane glycoprotein has been cloned by Chuang and McMahon (1999). Bak et al (2001) have cloned the human gene.
Hedgehog-interacting protein binds to the three mammalian hedgehog proteins Sonic hedgehog, Indian hedgehog, Desert hedgehog with an affinity comparable to that of the patched receptor and attenuates their bioactivities (Chuang and McMahon, 1999). Ectopic expression of the protein in
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