IF3 |
IFB |
PAS 2' |
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This factor (differentiation inhibitory factor; see also: DIF) is isolated from cell lysates and conditioned medium of the murine myeloid leukemia cell line M1 (16K I factor).
I factor inhibits the differentiation of these cells into monocytes and macrophages. This factor is identical with nucleoside diphosphate kinase encoded by the nm23 gene. The differentiation-inhibitory activity of this factor is not dependent on the kinase activity.
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