ICE-LAP3 |
ICE-like apoptotic protease-3 |
leucine rich repeat containing 70 |
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[ICE-like apoptotic protease-6] a cystein protease involved in cell death by apoptosis (Duan et al, 1996). Overexpression of ICE-LAP6 induces cell death by apoptosis in MCF7 breast carcinoma cells. ICE-LAP6 is processed proteolytically into an active cysteine protease by granzyme B. It has been suggested that ICE-LAP6 be renamed Caspase-9 (see: Caspases) (Alnemri et al, 1996). ICE-LAP6 is identical with MCH6.
For other entries pertaining to cell death mechanisms see also the Apoptosis and Cell Death Dictionary section of this encyclopedia.
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