ICF syndrome |
ICH-1L |
SAA2 |
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[ICE and CED3 homolog-1] ICH-1 is related to the Caenorhabditis elegans cell death gene CED3 and the mammalian homolog of CED3, IL1-beta Convertase. The two known forms of the mRNA encode proteins of 435 [ICH-1L] and 312 [ICH-1s] amino acids. Overexpression of the long form induces cell death by apoptosis. Overexpression of the short form suppresses Rat-1 cell death induced by serum deprivation (Wang et al, 1994).
ICH-1 has been shown to interact with another adaptor molecule, CRADD.
The human
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