ICH-2 |
ICH3 |
Ifi-6-16 |
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[ICE and CED3 homolog-3] The predicted amino acid sequence of ICH-3 shares 54 % identity with murine IL1-beta Convertase (Wang et al, 1996). Overexpression of ICH-3 in Rat 1 and HeLa cells induces cell death by apoptosis. This effect can be inhibited by crmA and BCL2. High levels ich ICH-3 are observed in vivo following stimulation with bacterial lipopolysaccharides, an inducer of septic shock. This enzyme is known now as Caspase-11. For nomenclature concerning related factors see: Caspases (Alnemri et al, 1996).
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