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IDF-45

[inhibitory diffusible factor-45] This monomeric factor of 45 kDa is isolated from the conditioned medium of confluent murine 3T3 cells. The known aminoterminal sequences demonstrates that this factor is related to rat and murine IGFBP3 (insulin-like growth factor binding protein-3) and it has been suggested that IDF-45 be called murine IGFBP3.

IDF-45 binds IGF (see also: IGFBP). It reversibly inhibits the growth of chicken fibroblasts and some other cell types. IDF-45 also inhibits the DNA synthesis in murine ... ... ... ... ... Subscribe to continue reading! ... ...

 

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