IF |
IF3 |
Class II tumor suppressor genes |
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[Inhibitor of F1F0-ATPase]; also Mitochondrial ATPase inhibitor protein, adenosinetriphosphatase inhibitor protein. Approved gene symbol: ATPIF1 [ATPase inhibitory factor 1]. This protein is a natural inhibitor of the enzyme complex that catalyzes the rate-limiting step of ATP formation in eukaryotic cells and inhibits up to 90 % of its ATPase activity without having any effect on ATP synthesis.
IF1 binds to several components of the synthase complex (Minauro-Sanmiguel, 2002; Cabezón et al, 2003), including the beta-subunit (see: ATP5B
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