ITLN2 |
ITM2Bs |
CBLN1 |
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(approved gene symbol) [integral membrane protein 2B] This protein of 266 amino acids (Pittois et al, 1998) shares the BH3 domain of BCL2 family members and exists in a long and a short form (ITM2Bs). The protein contains a Brichos domain; a databank synonym is BRICD2B [brichos domain containing 2B]. The gene encoding ITM2B has been identified independently as BRI. A stop codon in the BRI gene has been shown to be associated with familial British dementia (Vidal et al, 1999). Vidal R et al (2000) have reported that a decamer duplication in the 3' region of the BRI gene leads to the formation of a novel amyloid
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