IgE-dependent histamine releasing factor |
IgE enhancing factor |
Pentastatin-2 |
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[IgE enhancing factor] This factor is found in conditioned medium of a subset of T-helper cell clones. It can enhance synthesis of IgE and IgG1 in cultures of T-cell depleted spleen cells stimulated with bacterial lipopolysaccharides (Coffman and Carty, 1986).
The factor is identical with the IgE switch factor that causes isotype switching. Both factors are identical with IL4 (Snapper et al, 1988).
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