immunoglobulin domain C2 |
Immunoglobulin fold |
IK cytokine |
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also: immunoglobulin homology domains, immunoglobulin-like domains, immunoglobulin (Ig) domains; abbr. Ig-like domains, Ig domains. These protein domains of approximately 110 amino acids share amino acid sequences and structures with distinct protein domains found in immunoglobulins.
Structurally, these domains possess a distinctive immunoglobulin fold formed by two layers of antiparallel beta-pleated sheets connected with an internal disulfide bond. Each layer is composed of three to five polypeptide chains in antiparallel orientation (Bork et al, 1994). The most common topological subtypes of these domains are
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Some examples of proteins containing immunoglobulin domains may illustrate the extraordinary broad range of biological functions of the repective proteins although the functional contribution of the immunoglobulin domains have not been elucidated in detail:
CRTAM [cytotoxic and regulatory T-cell molecule]
DSCAM [Down syndrome cell adhesion molecule]
FGFR3 [fibroblast growth factor receptor-3]
FPRP Prostaglandin F2-alpha receptor regulatory protein]
ICAM2 [intercellular adhesion molecule 2]
IGSF11 immunoglobulin superfamily member 11
IL1RAPL2 [IL1 receptor accessory protein-like-2]
ILT11 [immunoglobulin-like transcript 11]
LINGO1 [LRR and Ig domain containing NOGO receptor interacting protein 1]
LMIR3 [leukocyte mono-Ig-like receptor 3]
PVRIG [Poliovirus receptor-related immunoglobulin domain-containing protein]
SIGIRR [single immunoglobulin domain-containing IL1R-related protein]
SIGLEC-3 [sialic acid binding immunoglobulin-like lectin 3]
SIRP-alpha-1 [signal regulatory protein-alpha-1]
SPIG1 [SPARC-related protein-containing immunoglobulin domains 1]
TEM5 [Tumor endothelial marker 5]
TIGIRR-1 [three immunoglobulin domain-containing IL1 receptor-related-1]
TIGIRR-2 [three immunoglobulin domain-containing IL1 receptor-related-2]
Tim-1 [T-cell immunoglobulin and mucin domain-containing protein 1]
Tim-2 [T-cell immunoglobulin and mucin domain-containing 2]
Tim-3 [T-cell immunoglobulin and mucin domain-containing 3]
Tim-4 [T-cell immunoglobulin and mucin domain-containing 4]
TMIGD2 [transmembrane and immunoglobulin domain containing 2]
VSIG3 [V-set and immunoglobulin domain containing 3]
VSIG4 [V-set and immunoglobulin domain containing 4]
VSIG9 [V-set and immunoglobulin domain containing 9]
For information on other protein domains and sequence motifs see also the Protein domains/sequence motifs Dictionary section of this encyclopedia.
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