KSHV orf16 |
KSHV orf50 |
NK inhibitory factor |
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This protein is encoded by an immediate-early gene of the Kaposi sarcoma-associated herpesvirus KSHV [Kaposi sarcoma-associated herpesvirus]. The viral protein interacts with cellular interferon regulatory factor-7 (IRF7), preventing its phosphorylation and accumulation in the nucleus of virus-infected cells. Since IRF7 is responsible for virus mediated activation of type 1 interferon genes this interaction prevents the activation of IFN-alpha and IFN-beta genes during viral infection.
For other entries pertaining to cell death mechanisms see also the Apoptosis and Cell Death Dictionary section of this encyclopedia.
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