KSHV orf54 protein |
KSHV orf63 |
Reg1 |
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[HHV-8 orf57] This open reading frame is contained within the genome of KSHV [Kaposi sarcoma-associated herpesvirus] KSHV). The protein is thought to be a homolog of ICP27 [infected cell protein 27] encoded by HSV-1 (Bello et al, 1999).
orf57 encodes a multifunctional protein of 455 amino acids that is essential for virus production (Han and Swaminathan, 2006). The protein is known also as KSHV MTA (for mRNA transcript accumulation) (or HHV-8 MTA) as it enhances mRNA transcript accumulation and RNA splicing of intron-containing viral RNAs and expression of various viral genes (Kirshner et al, 2000; Majerciak et al, 2008; Gupta et al, 2000).
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