KSHV orf74 |
KSHV orfK2 |
CHS1 |
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[orfK1]
[HHV-8 orfK1] The 46 kDa transmembrane glycoprotein K1 is encoded by a distinct open reading frame of KSHV (HHV-8) and possesses transforming properties, initiates signaling pathways in B-cells, and prevents cell death by apoptosis.
Expression of the K1 gene in rodent fibroblasts has been shown to produce morphologic changes and focus formation indicative of cell transformation. A recombinant herpesvirus expressing K1 immortalizes primary T-lymphocytes to IL2 independent growth and induces lymphomas
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