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[leukemia-associated inhibitory activity] LIA suppresses colony and cluster formation (see also: Colony formation assay) of hematopoietic cells (CFU-GM) obtained from normal donors but not from patients with leukemia. The factor has been identified as acidic isoferritin, a subclass of ferritin, which detoxifies, stores and transports iron (Broxmeyer et al, 1981, 1982).
An activity found in the conditioned medium of macrophages obtained from MDS bone marrow mononuclear cells of patients with myelodysplastic syndrome, designated MDS-IA [myelodysplastic syndrome-associated inhibitory activity] has been found to inhibit
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