Lto cells |
LTP-1 peptide |
SPARC |
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[liver-targeting peptide] This targeting peptide with the sequence acetyl-CKNEKKNKIERNNKLKQPPamide, consists of an N-terminal acetylcysteine followed by amino acids 76-93 of the N-terminal region of the circumsporozoite protein of Plasmodium berghei, Anka strain (Plasmodium circumsporozoite protein(76-93); abbr. CSP(76-93)). This peptide sequence is important for malarial sporozoite attachment to hepatocytes (Ancsin and Kisilevsky, 2004). Liposomes incorporating this peptide sequence target heparan sulfate binding sites in the liver (Robertson et al, 2008).
Jyothi et al (2015) have used modified nanoparticles functionalized with LTP to create a sustained drug delivery system for cyclophilin A
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