LDSF |
LDVKKIICVACKIKPNPACKKICPK |
Myelopid |
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[Leishmania donovani tyrosyl-tRNA synthetase] This aminoacyl-tRNA synthetase is encoded in the genome of the protozoan parasite Leishmania donovani. In the parasite, Tyrosyl-tRNA synthetase plays a canonical aminoacylation role during protein biosynthesis.
Heterozygous mutants show slower growth kinetics and attenuated virulence. LdTyrRS appears to be an essential gene as chromosomal null mutants do not survive. LdTyrRS protein is present in the cytoplasm and exits from the parasite cytoplasm into the extracellular medium. The released LdTyrRS functions as a neutrophil chemoattractant and has immunomodulatory functions, showing that it can be classified as a moonlighting protein. LdTyrRS specifically binds to host macrophages with its ELR
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