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M20 interleukin-1 inhibitor

This biochemically uncharacterized factor of approximately 52 kDa is found in the conditioned medium of the human myelomonocytic cell line M20 (Barak et al, 1986). The protein is distinct from IL1ra (IL1 receptor antagonist) (Barak et al, 1991). It specifically blocks processes induced by IL1 in vitro and in vivo and acts specifically on IL1 induced responses in vivo Barak et al, 1993, 1993). Among other things the factor ameliorates acute inflammatory responses such as fever, leukocytosis, enlargement of lymph nodes, and the expression of acute phase proteins in experimental animals (see also: acute phase reaction, inflammation).

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