MANF

(approved gene symbol) [mesencephalic astrocyte-derived neurotrophic factor] This secreted 20 kDa protein was identified originally in a rat cell line established from mesencephalic type 1 astrocytes (Petrova et al, 2003). The human gene has been cloned by Petrova et al (2003). The protein has been identified independently as ARP [arginine-rich protein] and is being referred to also as ARMET [arginine-rich protein mutated in early stage tumors].

Petrova et al (2003) have reported that MANF selectively protects nigral dopaminergic neurons, versus GABAergic or serotonergic neurons. MANF is more selective than ... ... ... ...
 
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Entry last modified: September 2019