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MANF

(approved gene symbol) [mesencephalic astrocyte-derived neurotrophic factor] This secreted 20 kDa protein was identified originally in a rat cell line established from mesencephalic type 1 astrocytes (Petrova et al, 2003). The human gene has been cloned by Petrova et al (2003). The protein has been identified independently as ARP [arginine-rich protein] and is being referred to also as ARMET [arginine-rich protein mutated in early stage tumors].

Petrova et al (2003) have reported that MANF selectively protects nigral dopaminergic neurons, versus GABAergic or serotonergic neurons. MANF is more selective than GDNF or ... ... ... ... ... Subscribe to continue reading! ... ...

 

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