MD-HBGF
[macrophage-derived HBGF] This factor of 14-25 kDa is found in the conditioned medium of monocytes that have undergone differentiation into macrophages after in vitro culture (Besner et al, 1990). The factor binds heparin. It promotes stimulation of DNA synthesis in 3T3 cells and stimulates the proliferation of vascular smooth muscle cells, but not proliferation of vascular endothelial cells.
MD-HBGF is not identical to other heparin binding 3T3 cell growth factors, including PDGF-AA, PDGF-BB, PDGF-AB, aFGF, bFGF.
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