MERS-CoV ORF5 |
MERTK |
viral MIP-3 |
||
[Middle East respiratory syndrome coronavirus ORF8b] this open reading frame in the genome of MERS-CoV [Middle East respiratory syndrome coronavirus], the causative agent of severe-to-fatal pneumonia, encodes one of several viral accessory proteins. This virulence factor strongly inhibits the IFN-beta promoter activity promoted by the two pattern recognition receptors MDA-5 and RIG-I. Downstream signaling molecules are left largely unaffected. MDA-5 protein levels are down-regulated significantly by MERS-CoV ORF8b and co-expression of MERS-CoV ORF4a and MERS-CoV ORF4b (Lee et al, 2019).
For other relevant entries see also the Pathogenicity/Virulence Factors Dictionary
...
...
...
...
... Subscribe to continue reading!
... ...
Content view restricted ! |
| SUPPORT COPE | Intro | Subdictionaries | New Entries | Contribute data | COPE Credentials |
| # | A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z |
|
Created, developed, and maintained by Dr H Ibelgaufts
|
U L T R A P O S S E N E M O O B L I G A T U R