MFAP5 |
MFF |
TRAIL receptor inducer of cell killing-2 |
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This cell line has been developed by Tesseur et al (2006). The cells can be used in bioassays of TGF-beta.
The cells are embryonic fibroblasts from knock-out mice lacking expression of TGF-beta-1 and have been engineered to express a reporter plasmid directing the synthesis of secreted alkaline phosphatase in response to tratment with TGF-beta-1, TGF-beta-2, and TGF-beta-3. The cells show more than 1000-fold induction after stimulation with 1 ng/mL TGF-beta-1, and detect as little as 1 pg/mL TGF-beta-1. Related TGF family members such as activin,
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