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MI

[metalloproteinase inhibitor] This protein is one of two proteins identified in the conditioned medium of bovined aortic endothelial cells. The protein has antiproteinase activity and inhibits collagenase, type 4 collagenase, and gelatinases, but not trypsin, plasmin or bacterial collagenase (De Clerck et al, 1989). The cDNA has been cloned by Boone et al (1990). Sequence analysis and functional studies show that this protein is the bovine homolog of the inhibitor of metalloproteinase TIMP-2. In some older publications the protein is also being referred to as MI/TIMP-2.

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